This article is part of our Football Predictions series.
Premier League GW25 Betting Tips: Man United vs Spurs & Liverpool vs Man City
Premier League Gameweek 25 features several marquee fixtures with strong betting interest, including Manchester United vs Tottenham and Liverpool vs Manchester City. Below are our GW25 betting tips and predictions, focusing on game script, matchup dynamics, and where betting markets may present value.
This article accompanies our full GW25 Premier League betting video and podcast, providing a written breakdown of each matchup for bettors preparing ahead of kickoff.
Quick Betting Overview (GW25)
• Man United vs Tottenham: Tactical matchup, totals in focus
• Newcastle vs Brentford: Home control vs efficiency
• Liverpool vs Man City: Market likely overvalues goals
Tools & Resources
Premier League Cheat Sheets - Predicted Lineups, Odds, Stats
RotoWire Soccer Betting Pages - Odds Comparisons, Futures
Predicted & Confirmed Premier League Lineups - 75 Minutes Before KO
Injuries & News - Player Updates After Friday Press Conferences
Watch: GW25 Premier League Betting Picks
Listen: Full GW25 Betting Podcast
GW25 Match-by-Match Predictions
We break down all three fixtures with game script expectations, betting leans, and total outlooks.
Manchester United vs. Tottenham
Manchester United and Tottenham meet in a fixture that often looks open on paper but can tighten quickly depending on lineup choices and game state. United's ability to control midfield tempo has been inconsistent, while Tottenham have been erratic throughout the season no matter how they attack a match.
Both sides have shown a willingness to slow matches when leading, which can cap scoring despite attacking talent on the pitch.
Game script: United expected to control and rack up chances
Lean: Man United moneyline
Goal expectation: High
Betting angle: Under consideration for higher goal totals depending on lineups; Man United on the handicap
Newcastle vs. Brentford
Newcastle's home intensity contrasts with Brentford's structured, efficiency-driven approach. Brentford are rarely drawn into chaotic matches unless forced, while Newcastle are content to build pressure gradually rather than push all-out tempo.
Set pieces and physical duels are likely to play a major role in deciding this matchup, as well as the status of Bruno Guimaraes in the midfield. Anthony Gordon has already been ruled out.
Game script: Newcastle control territory; Brentford counter selectively
Lean: Newcastle
Goal expectation: Low to medium
Betting angle: Newcastle to win; selective unders and Newcastle set-piece related markets
Liverpool vs. Manchester City
This is the headline fixture of GW25 and one of the most complex betting puzzles of the weekend. Both sides are capable of controlling possession for long stretches, and neither is likely to commit excessive numbers forward early.
Recent meetings between these teams have often been more tactical than explosive, particularly when both managers prioritize control over chaos, at least since Arne Slot took over.
Liverpool will try to ride momentum from Newcastle win, while City are looking to do the same after also beating Newcastle in the EFL Cup.
Game script: Tactical, high-quality but controlled match
Lean: Liverpool; Draw
Goal expectation: Medium to high
Betting angle: Overs, draw or split-result angles depending on prices
Final Thoughts
Gameweek 25 is shaped more by match control and tactical balance than outright mismatches. Several high-profile fixtures may not play to public expectations, making disciplined market selection and timing especially important.
Be sure to check back closer to kickoff for confirmed lineups and late betting updates, and follow along with our Premier League betting video and podcast for full discussion on each fixture.
