With Doug Martin out, rookie Mike James takes center stage for the Buccaneers, and for fantasy owners needing running-back help.
Sam Bradford's season-ending knee injury opens the door for backup Kellen Clemens to start in St. Louis, unless the Rams reach out to someone like, say, Vince Young.
Fantasy owners in IDP leagues are going crazy over Bills rookie linebacker Kiko Alonso, who leads the league in both tackles and interceptions.
With the Falcons hurting at wide receiver, Tony Gonzalez is expected to see a heavy workload, making him a favorite of Kevin Payne's this week on FanDuel.
The Packers are the better bet for this week, but Ryan Tannehill and the Dolphins offer a far better payout.
San Francisco tight end Vernon Davis is seeing more targets thanks to the reliable double-teams thrown Anquan Boldin's way.
Ray Flowers believes that Cam Newton remains among the elite quarterbacks, among other notes this week.
A frequent debate when discussing wide receivers is the effect of one top wideout when the team loses another one to injury. This week Jordy Nelson's owners face that dilemma - more targets vs. more attention.