Orlando City's Dom Dwyer has two goals on 15 shots over his last three games, and RotoWire's Schuyler Redpath is expecting the high production to continue Saturday against New England.
Monterrey are big favorites at home against Queretaro on Saturday, which means fantasy players are likely considering how big of a stack to build.
Montreal has a great matchup at home against D.C. United on Saturday, which means fantasy players could turn to Ignacio Piatti.
Friday's two-game slate doesn't include an overwhelming favorite, which means fantasy players should be able to diversify their lineups.
Tigres and Monterrey are the favorites on Sunday's two-game slate, which means Andre-Pierre Gignac could be a popular option.
With Romain Alessandrini suspended due to yellow card accumulation, the Galaxy will need to rely even more on Zlatan Ibrahimovic in their attack.
The Galaxy are big favorites at home against Orlando City on Sunday, and fantasy players are likely to give a long, hard look toward Zlatan Ibrahimovic.
Houston could have a tough time against the Timbers in Portland on Saturday, but they always have a chance with the dangerous Alberth Elis in their attack.
Club America are big favorites at home to Atlas on Saturday, while the Chivas-Cruz Azul match expected to be very close.
Diego Valeri has been churning out the fantasy points this season, and RotoWire'e Schuyler Redpath thinks he'll keep it going Saturday against Houston.
Toronto FC is the big favorite on Saturday's slate, with the oddsmakers naturally expecting Sebastian Giovinco to have a big impact.
Both away teams are favored on Friday's two-game Liga MX slate, but that doesn't mean fantasy players should be avoiding hosts Morelia and Puebla.
David Villa could return from injury Thursday, and the oddsmakers are expecting him to have a big impact on the road at Orlando City.
The Red Bulls are favored away to D.C. United on Wednesday, which is likely to get plenty of people looking to Bradley Wright-Phillips for at least one goal.
Los Angeles FC is favored away to Minnesota United on Sunday, and fantasy players will have to decide if Carlos Vela is worth his very high price.
The Red Bulls are big favorites at home to the Revolution on Saturday, and the oddsmakers think Bradley Wright-Phillips has a great chance to find the back of the net.
The new Liga MX season kicks off Friday, with Veracruz and Atlas both expected to win while hosting Pumas and Queretaro, respectively.
The Revolution are road underdogs to Minnesota United on Wednesday, but Diego Fagundez can still make a meaningful fantasy impact.