This article is part of our Football Predictions series.

Premier League GW16 Predictions: Betting Picks for Every Match

Gameweek 16 of the Premier League features a full slate of fixtures, and with midweek congestion, rotation risk, and fixture swings in play, it's a key week for bettors to stay selective. Below are our GW16 predictions and betting picks for every match, including projected game scripts, goal expectations, and matchup notes.

You can also watch the full GW16 betting breakdown and listen to the podcast episode for deeper analysis on each fixture.

Tools & Resources

Premier League Cheat Sheets - Predicted Lineups, Odds, Stats

RotoWire Soccer Betting Pages - Odds Comparisons, Futures

Predicted & Confirmed Premier League Lineups - 75 Minutes Before KO

Injuries & News - Player Updates After Friday Press Conferences

Watch: GW16 Premier League Betting Picks

Listen: Full GW16 Betting Podcast

GW16 Match-by-Match Predictions

We break down all 10 matches for Gameweek 16, including sides, totals, props and match trends.

Chelsea vs. Everton

Chelsea continue to improve in buildup and pressing, while Everton remain conservative away from home. Will Reece James be rested? Will Cole Palmer start again?

Game script: Chelsea control possession but struggle to produce
Lean: Draw
Goal expectation: Medium
Betting angle: Under 2.5

Liverpool vs. Brighton

This matchup typically produces chances at both ends, with Brighton willing to play through pressure. Are Liverpool past the Mohamed Salah issues? Can they secure a clean sheet against a pressing side?

Game script: High tempo, open phases, goals
Lean: Draw, Brighton double chance
Goal expectation: High
Betting angle: Over goals / Team totals

Burnley vs. Fulham

Both teams in need of points near the bottom of the table. Can Fulham take three points away from home where Burnley have been better?

Game script: Low tempo, few clear chances
Lean: Draw or Fulham narrow edge
Goal expectation: Low
Betting angle: Under 2.5 / Fulham win

Arsenal vs. Wolves

Arsenal should dominate territory, especially against a Wolves side that struggles to defend sustained pressure. Do Wolves have a chance no matter who starts for the Gunners?

Game script: Arsenal control
Lean: Arsenal win with clean sheet
Goal expectation: Medium
Betting angle: Arsenal -1.5 / Win with clean sheet

Crystal Palace vs. Manchester City

City's away control and chance creation give them a strong edge, even if Palace look to counter. Still, Palace always seem to score in this matchup and there should be goals.

Game script: City possession, Palace transitions
Lean: Man City win
Goal expectation: Medium–High
Betting angle: Over 2.5

Nottingham Forest vs. Tottenham

Forest are playing better, but how much better than Ange Postecoglou days? Tottenham have some form and could get another road win.

Game script: Could be limited chances given Sean Dyche system
Lean: Spurs win
Goal expectation: Medium
Betting angle: Spurs moneyline

Sunderland vs. Newcastle

A derby where intensity may outweigh quality early. Never bet against Sunderland at home, especially in a derby.

Game script: Cagey start, emotional game
Lean: Newcastle edge but doesn't matter at Stadium of Light
Goal expectation: Low
Betting angle: Sunderland win or draw

West Ham vs. Aston Villa

Villa's structure and West Ham's counterattacking style often create narrow margins. Villa have won eight straight and hard to bet against in this spot.

Game script: Tactical, patient
Lean: Aston Villa win
Goal expectation: Medium
Betting angle: Villa ML and both teams to score

Brentford vs. Leeds

Both teams prefer direct play, which can create chances quickly. Leeds may have more possession but Brentford will live off counter. Expect open play with corners.

Game script: Fast, open spells
Lean: Brentford win
Goal expectation: High
Betting angle: Over 3.5 / Brentford team total / Over corners

Manchester United vs. Bournemouth

United's home advantage matters, but defensive lapses keep Bournemouth live. What will the absences be for a Monday night showdown?

Game script: United control with moments of chaos
Lean: Close, draw
Goal expectation: Medium
Betting angle: Under 2.5 / Draw

Final Thoughts

Gameweek 16 is about game flow and rotation awareness. Markets can be slow to adjust to squad turnover and compressed scheduling, creating opportunity for bettors who focus on tempo and matchup profiles rather than raw form.

For full context, including score ranges and live discussion of each match, watch the GW16 betting video and listen to the podcast episode embedded above.