Premier League GW12 Betting Picks: Newcastle vs Man City, Arsenal vs Spurs & Best Bets

Written by

Christopher Owen

Adam Zdroik

Published on November 21, 2025

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Premier League GW12 Betting Picks: Newcastle vs Man City, Arsenal vs Spurs & Best Bets

The Premier League returns with a massive Gameweek 12 slate, headlined by Newcastle vs Manchester City and the North London Derby between Arsenal and Tottenham. Below are our best bets, predictions, value plays and match breakdowns, with the full betting show and podcast episode embedded for deeper analysis.

Tools & Resources
Premier League Cheat Sheets - Predicted Lineups, Odds, Stats
RotoWire Soccer Betting Pages - Odds Comparisons, Futures
Predicted & Confirmed Premier League Lineups - 75 Minutes Before KO
Injuries & News - Player Updates After Friday Press Conferences

GW12 Best Bets & Betting Predictions

This week's betting card features two marquee fixtures and several strong angles in totals, props, and match lines. Below are the top plays with context from form, injuries and tactical trends.

Newcastle vs Manchester City Betting Preview

Man City enter GW12 with full health following the international break, while Newcastle have questions across the pitch, including in net with Nick Pope coming off a concussion.

Key Betting Notes

Newcastle stronger at St. James' Park. Does it matter?
Jeremy Doku vs. Kieran Tripper. Does Eddie Howe make an adjustment?
Can Newcastle stop in-form Erling Haaland?

Newcastle vs. Man City Best Bets

Haaland to score & Man City to win
Under 2.5 goals

Arsenal vs Tottenham: North London Derby Betting Picks

Arsenal host Spurs in one of the most volatile derbies in Europe. Arsenal want to add to their cushion atop the table while Tottenham are just hoping to find any kind of consistency.