NFL Picks: 49ers vs. Colts Odds, Picks, and Predictions for MNF Week 16

This article is part of our NFL Picks series.

NFL Picks: 49ers vs. Colts Odds, Picks, and Predictions for MNF Week 16

Cap off the NFL Week 16 action with our NFL picks for Monday Night Football. The San Francisco 49ers (10-4) travel to Indianapolis to take on the Colts (8-6) in an inter-conference matchup on Monday Night Football. The Colts are coming in on a four-game skid and a tough loss to the Seahawks 18-16. while the 49ers are on a four-game winning streak and off a huge win against the Titans 37-24.

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San Francisco 49ers vs. Indianapolis Colts Betting Odds

• Colts +6.0 (BetRivers -109) / 49ers -5.5 (Caesars Sportsbook -114)  
• Colts ML (FanDuel +225) / 49ers ML (BetMGM -250)
• Total OVER 46.0 (Hard Rock -110) / UNDER 46.5 (FanDuel -105) 
• Colts total points: Over 20.5 (DraftKings) / Under 20.5 (DraftKings)
• 49ers total points:  Over 26.5 (DraftKings) / Under 26.5 (DraftKings) 
• First-half spread: Colts +3.5 (DraftKings) / 49ers -2.5 (FanDuel)            
• First-half total: Over 23.5 (DraftKings) / Under 23.5 (Hard Rock)
• First-half team total: 
  • Colts Over/Under 9.5 (Caesars Sportsbook) 
  • 49ers Over/Under 13.5 (Caesars Sportsbook)      
• Weather - Dome

The 49ers opened as 3-point home favorites, and it reopened at -6 and climbed to -7. It came down to -4.5 on Dec. 14, then went back up to -5.5, -6, -6.5, and is now -6.     

The total opened at 46.5 and reopened on December 9th at 45.5 and is now at 46. 

The majority of the bets (59 percent) have come in on the 49ers, and the handle is 71 percent on San Francisco also, which is indicative of where the SHARP money is coming from. 

The total has 59 percent of bets, and the money is on the OVER.  The moneyline is on the 49ers at 89 percent of the bets, and 86 percent of the money. 

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Colts vs. 49ers Betting Picks 

BETTING TRENDS

• San Francisco is 5-1 ATS in its last 6 games.
• The total has gone OVER in 4 of San Francisco's last 6 games.
• San Francisco is 5-1 SU in its last 6 games.
• San Francisco is 1-4 ATS in its last 5 games against Indianapolis.
• Indianapolis is 2-4 ATS in its last 6 games.
• The total has gone UNDER in 4 of Indianapolis' last 6 games.
• Indianapolis is 1-5 SU in its last 6 games.
• Indianapolis is 8-1 SU in its last 9 games at home.

NFL Team Rankings

Colts vs. 49ers Best Bets

• Colts UNDER 20.5 points for 1 unit (DraftKings +100)
• 49ers/Colts UNDER 46.5 for 1 unit (Fanatics -110)
• Brock Purdy OVER 240.5 passing yards for 0.5 unit (Fanatics -120)
• Jauan Jennings Anytime TD for 0.5 unit (Hard Rock +155)

Colts vs. 49ers Predictions

It has been the tale of two seasons for the Colts, who started off 7-1, but they are just 1-5 in their last 6 games. Their schedule was a big part of that early season success, as they have played 4 Top 8 teams over the last four weeks. 

The injury to QB Daniel Jones could have crippled their season, but QB Philip Rivers was serviceable against the Seahawks in a game they could have won. 

49ers QB Brock Purdy should be able to move the ball in the air, and the 49ers go on to win Monday night. 

49ers 27, Colts 16