This article is part of our Injury Analysis series.
Hotspots on this week's NFL injury report include Buffalo's offensive tackles, Carolina's interior O-line and Arizona's backfield. Make sure to keep up with NFL breaking news throughout the weekend, especially Sunday morning when inactive lists are released at 11:30 a.m. ET for the early games.
Below you'll find four different categories, with our lists including key offensive linemen and defensive players whose absences might impact fantasy decisions. The bottom section, for potential game-day decisions, is sorted by kickoff times. It can be used as a checklist/cheatsheet for Sunday when inactives come out and we need to adjust lineups.
Good to Go 💯
Players that missed their team's previous game are listed in bold.
Cleared to Play this Week
QB Jaxson Dart (concussion)
QB Aaron Rodgers (wrist)
QB C.J. Stroud (concussion)
QB Daniel Jones (fibula)
RB Devin Neal (ankle)
RB Ashton Jeanty (ankle)
RB Kenneth Walker (glute)
RB Chris Rodriguez (illness)- WRs Terry McLaurin (quad), Jaylin Lane (hip) & Treylon Burks (finger)
WR Brian Thomas (ankle)- WR DK Metcalf (ankle)
- WR Tre Tucker (knee)
TE David Njoku (knee)
Broncos CB Patrick Surtain II has no injury designation for Sunday night's game against Washington and is good to go.
— Adam Schefter (@AdamSchefter) November 28, 2025
Ruled Out/Doubtful 🚑
New absences listed in bold (guys that played in the previous game).
Out/Doubtful/IR
QB J.J. McCarthy (concussion)- QB Jayden Daniels (elbow)
RBs Trey Benson (IR - knee) & Emari Demercado (ankle)- RB Alvin Kamara (knee)
RB Omarion Hampton (IR - ankle)
WR Drake London (PCL)- WR Noah Brown (groin/knee)
WR Xavier Gipson (shoulder)
WR Curtis Samuel (IR - shoulder)- TE Brenden Bates (ankle)
- TE Michael Mayer (ankle)
TE Nate Adkins (knee)
K Eddy Pineiro (hamstring)
Potential Workload Beneficiaries (From Injuries Above)
- QB Max Brosmer
- QB Marcus Mariota
- RBs Bam Knight (ankle) & Michael Carter
- RB Devin Neal
- RB Kimani Vidal
- WRs Darnell Mooney, David Sills & Dylan Drummond
- K Matt Gay
Key Defensive Players + Offensive Linemen
- RG Patrick Mekari (head), DE Travon Walker (knee)
C Lloyd Cushenberry (foot), DT Shy Tuttle (head), CB Jalyn Armour-Davis (foot)
C Cade Mays (ankle), G Chandler Zavala (calf)- CB Jaycee Horn (head), LB Christian Rozeboom (hip)
- MLB Tatum Bethune (ankle), DE Sam Okuayinonu (ankle)
- DT Walter Nolen (knee), G Will Hernandez (hip)
- G Donovan Jackson (ankle)
- LT Dion Dawkins (head), RT Spencer Brown (shoulder), LB Terrel Bernard (elbow)
- OT Broderick Jones (neck), DT Derrick Harmon (knee)
G Jared Wilson (ankle)
Bills now have ruled out both starting tackles, LT Dion Dawkins and RT Spencer Brown, along with LB Terrel Bernard and WR Curtis Samuel for Sunday's game vs. the Steelers.
Josh Allen was sacked a career-high eight times last week. pic.twitter.com/gy5x0SAMZc
— Adam Schefter (@AdamSchefter) November 28, 2025
Listed as Questionable - Should Play 👍
QB Baker Mayfield (shoulder)- RB Bucky Irving (shoulder/toe)
Final injury report for Bucs-Cardinals…Baker Mayfield and Bucky Irving both officially listed as questionable. The expectation is that Irving will play and as Bowles said earlier today, Mayfield is trending in the right direction. pic.twitter.com/0rmTmpUaat
— JennaLaineESPN (@JennaLaineESPN) November 28, 2025
Truly Questionable / Game-Time Decisions 🤔
Players with key fantasy repercussions listed in bold.
Early Games
- RB Bam Knight (knee)
- RB Jerome Ford (hamstring)
- WR Marvin Harrison (appendix)
- WR Chris Olave (back)
- WR Elic Ayomanor (hamstring) & TE Chig Okonkwo (foot)
TE Darren Waller (IR -pectoral)
Knight seems likely to play after limited practices all week, though he's listed with a knee injury (after being listed with an ankle problem the previous week). Olave also seems more likely than not to play, while Harrison I don't have a read on.
In Waller's case, the Dolphins will need to activate him from injured reserve by 4 p.m. ET on Saturday if he's going to play Sunday against New Orleans.
"Some things feel uncomfortable. Some things feel kinda normal."
Cardinals WR Marvin Harrison Jr. on his practice ramp-up this week after missing the past two games due to an appendectomy ⬇️ pic.twitter.com/XhBxyDTuo0
— Tyler Drake (@Tdrake4sports) November 28, 2025
Harrison sure seems like he is trending to play, however.
— Darren Urban (@Cardschatter) November 28, 2025
Late-Afternoon Games
- WR Joshua Palmer (ankle)
- TE Dalton Kincaid (hamstring)
Primetime Games
- WRs Wan'Dale Robinson (ankle) & Darius Slayton (hamstring)
Robinson and Slayton both have been limited practice participants and seem more likely than not to play.
Key Defensive Players + O-Linemen
- OT Dan Moore (knee), S Xavier Woods (hamstring)
S Kamren Kinchens (shoulder), DT Poona Ford (calf)
DT Harrison Phillips (foot), CB Jarvis Brownlee (hip)- RG Chris Lindstrom (foot)
- CB Rasul Douglas (foot), DT Benito Jones (ankle), RT Austin Jackson (IR - toe)
- OT Kelvin Beachum (groin), CB Max Melton (heel)
- G Ben Bredeson (hamstring), OLB Haason Reddick (ankle)
- S Ty Okada (oblique)
- LT Christian Darrisaw (foot), OLB Jonathan Greenard (shoulder)
- S Josh Metellus (knee), S Theo Jackson (neck), DT Jalen Redmond (hip)
- RG Jordan Meredith (ankle), SCB Darnay Holmes (ill), DT Adam Butler (ill)
- DT Dexter Lawrence (elbow), OLB Kayvon Thibodeaux (shoulder), CB Paulson Adebo (knee)
- OLB Harold Landry (knee), DY Khyiris Tonga (chest)
