Most Injured NFL Teams of 2025: Ranking Man-Games Missed

Injuries reshaped the NFL in 2025, but "who got hurt" doesn't always capture the full story. To measure which teams were hit hardest, we ranked every club by man-games missed—a team-level snapshot of how many player-games were lost throughout the regular season. We also included Players and Man-Games per Player to show whether injuries were widespread or concentrated among fewer players. 

We combined injury-related data from Spotrac and Pro Football Reference (PFR) to calculate team injury burden across the 2025 regular season. Using PFR injury-report information, we calculated man-games missed at the team level (player-games lost due to injury designations). 

From Spotrac, we pulled each team's season injury player count to provide context for how broadly injuries impacted the roster. 

Finally, we calculated man-games per player to highlight which teams dealt with longer absences per injured player versus teams that absorbed injuries across more players.

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NFL's Most Injured Teams of 2025 

Which Teams Ranked Atop the League?  

Looking back at the season that was, it's no wonder that the Arizona Cardinals bottomed out in 2025, with the NFC West stalwarts going 3-14, ultimately costing head coach Jonathan Gannon his job in the process.  

The Cardinals finished the year as the NFL's leader in in terms of injured players overall (32) and games missed by those injured players (303), speaking to the franchise's -5 year-over-year win total (from the team's 8-9 finish in 2024).  

Among the players in the Valley that missed serious time with injuries were QB Kyler Murray, who missed 12 games in total, while 2024 first round pick Marvin Harrison Jr. (five games), 2025 first-round pick Walter Nolen (11 games) and cornerbacks Kei'Trel Clark (three games) and Garrett Williams (seven games) joined safety Kitan Crawford (two games) in missing serious time in 2025.  

All told, Arizona's walking wounded beat out the NFL's other injury-plagued units, including the second-place Detroit Lions (28 injured players/274 games missed) and Miami Dolphins (24 injured players/265 games missed).  

Throw in the fourth-place San Francisco 49ers (19 injured players/254 games missed) and the Buffalo Bills (17 injured players/246 games missed) and you have the upper end of the league's injury rankings covered.  

Of those five, only the Niners and Bills made the postseason, with both still alive in their respective league's Divisional Round showdown this weekend, with San Francisco listed as a seven-point road underdog against the Seattle Seahawks, while Buffalo's listed as a 1.5-point road underdog in Denver, according to oddsmakers from DraftKings Sportsbook.  

Which NFL Teams Were Spared (Injury Wise) in 2025?  

While we've covered the NFL's most-injured teams in depth above, the teams that fared the best when it came to the injury bug weren't necessarily the most successful.  

That's because the squad that managed to finish the year with the fewest player missed games was the lowly Las Vegas Raiders, who had 83 games missed in total on a team that went 3-14 this season.  

The second-best team, injury wise, was the Los Angeles Rams, who are still alive in the NFC after beating the NFC South-champion Carolina Panthers in Charlotte in the Wild Card Round, 34-31.  

In total, L.A. had 88 games missed in total, finishing ahead of the Jacksonville Jaguars (117 games missed) and the Cincinnati Bengals (127 games missed), with the Jags' being the only team of the latter two to make the postseason, going 13-4 and winning the AFC South crown for the first time since 2022 before bowing out in the Wild Card Round at home to the Buffalo Bills, 27-24.  

Things weren't any rosier in the Queen City, with the Bengals bottoming out at 6-11 and missing the playoffs entirely, reminding fans that avoiding injuries isn't a guaranteed way to succeed in today's world of professional football.