Isaac Brown

Running BackRB
2024 Fantasy Outlook
Brown's 2025 season commenced with him working in a backfield committee alongside Maurice Turner, Keyjuan Brown, Duke Watson and Donald Chaney. By Week 5, Brown started to emerge as the top option in the backfield, amassing 13 carries for 72 yards and four grabs for 23 yards and a score in the contest. He served in more of a workhorse role down the stretch, handling at least 50 percent of the rushing attempts in five of the last games and 43 percent against Miami. The only two games he didn't? A game against Stanford in which he missed most of the game due to injury, and the subsequent week against Pitt in a blowout win. Watson is definitely an intriguing option behind Brown, but all signs point to Brown claiming a clear lead role in an explosive Cardinals offense in 2025, which should result in an improvement on his 147 carries for 1,074 yards and 11 touchdowns and 30 grabs for 152 yards and a score over the 12 regular-season contests last season, making him a top-flight fantasy running back option. Read Past Outlooks
Will return to Louisville
January 4, 2026
Brown will return to Louisville for his 2026 season, Connor Stanley of On3 reports.
ANALYSIS
Barring setbacks, Louisville's team does not need to worry about finding a top running back for 2026. As part of the 2024 Cardinals, he logged 165 rushing attempts for 1,173 yards and 11 touchdowns. Despite his 2025 not being as productive, Brown proved that he is a reliable RB1. Across fewer games, he logged 101 carries for 884 yards and seven touchdowns. Brown recorded 8.8 yards per rushing attempt, an improvement to his 2024 season's 7.1 YPA.
Read More News
College Football Stats
Loading CFB Stats...
2025
2024
2025 CFB Game Log
calculator icon
Calculate Stats Over Time
Just click on any two dates.
Scoring
FanDuel
DraftKings
Head2Head
Loading Game Log...
2024 CFB Game Log
calculator icon
Calculate Stats Over Time
Just click on any two dates.
Scoring
FanDuel
DraftKings
Loading Game Log...
Cardinals Depth Chart
Our full team depth charts are reserved for RotoWire subscribers.
Subscribe Now
Recent RotoWire Articles Featuring Isaac Brown See More
Louisville vs. Toledo Picks and Predictions for the Boca Raton Bowl
31 days ago
Tuesday's Boca Raton Bowl features a showdown of Louisville versus Toledo. Get expert picks, predictions and best bets for the early afternoon contest.
College Football Picks: Louisville vs. SMU
63 days ago
Dig into the key ACC showdown between SMU and Louisville as Chris Morgan digs into the odds along with his best bets and player props to target Saturday.
FanDuel College Football DFS: Saturday Week 13 Main Slate Picks
63 days ago
College football DFS picks for Saturday's main slate on FanDuel. Jeremiyah Love should get a healthy dose in a simple recipe to blow by Syracuse, but who else should you target this week?
College Football DFS: DraftKings CFB Saturday Main Slate for Week 10
84 days ago
Expert CFB DFS picks for Saturday's main slate, including Julian Sayin as he and the Buckeyes play host to a struggling Penn State squad.
College Football Picks: Miami vs Louisville
98 days ago
The Miami Hurricanes host the Louisville Cardinals in a thrilling ACC showdown. Will Miami cover the spread? Discover expert betting insights on the contest for both the game and player props!
More Fantasy News
Entering transfer portal
RBNo Current School
Transfer Portal
January 1, 2026
Brown will enter the NCAA transfer portal, per Hayes Fawcett of On3.com.
ANALYSIS
Subscribe now to instantly reveal our take on this news.
Two touchdowns during bowl game
December 24, 2025
Brown totaled 10 rushes for 102 yards and two touchdowns and hauled in all two targets for six yards during Tuesday's 27-22 victory versus Toledo.
ANALYSIS
Subscribe now to instantly reveal our take on this news.
Will play bowl game
December 23, 2025
Brown (lower leg) will play in Tuesday's bowl game with Toledo, Mark Blankenbaker of ESPN Louisville reports.
ANALYSIS
Subscribe now to instantly reveal our take on this news.
Out for Week 14
Lower Leg
November 29, 2025
Brown (lower leg) is out for Saturday's game against Kentucky, Pete Thamel of ESPN reports.
ANALYSIS
Subscribe now to instantly reveal our take on this news.
Questionable for Week 14
Lower Leg
November 29, 2025
Brown (lower leg) is questionable for Saturday's game against Kentucky, Pete Nakos of On3.com reports.
ANALYSIS
Subscribe now to instantly reveal our take on this news.